CBX4 anticorps (AA 401-500) (AbBy Fluor® 647)

N° du produit ABIN6980050

Cet anticorps Lapin Polyclonal détecte spécifiquement CBX4 dans WB, IF (cc) et IF (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour CBX4 anticorps (AA 401-500) (AbBy Fluor® 647) (ABIN6980050)

Antigène: CBX4 (Chromobox Homolog 4 (CBX4))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBX4 est conjugé à/à la AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-CBX4 anticorps (AbBy Fluor® 647)

Épitope: AA 401-500

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CBX4

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur CBX4

Antigène: CBX4 (Chromobox Homolog 4 (CBX4))

Autre désignation: CBX4

Sujet:

Synonyms: PC2, NBP16, E3 SUMO-protein ligase CBX4, Chromobox protein homolog 4, Polycomb 2 homolog, hPc2, CBX4

Background: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

ID gène: 8535

UniProt: O00257