PAK7 anticorps (Biotin)

N° du produit ABIN6983011

Cet anticorps Lapin Polyclonal détecte spécifiquement PAK7 dans IHC (p). Il présente une réactivité envers Rat.

Aperçu rapide pour PAK7 anticorps (Biotin) (ABIN6983011)

Antigène: PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAK7 est conjugé à/à la Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-PAK7 anticorps (Biotin)

Réactivité croisée: Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human PAK5

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur PAK7

Antigène: PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7))

Autre désignation: PAK5

Sujet:

Synonyms: Mbt, mushroom bodies tiny, Pak2,p21 activated kinase 7, p21 protein (Cdc42/Rac)-activated kinase 7, p21(CDKN1A) activated kinase 7, p21-activated kinase 5, p21-activated kinase 7, PAK 5, PAK7, PAK 7, PAK-5, PAK-7, PAK5, PAK7, Protein kinase PAK5, Serine/threonine protein kinase PAK 7, MBT, Serine/threonine-protein kinase PAK 7, PAK7_HUMAN, Protein kinase PAK5.

Background: The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] Function : Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. Subunit : Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with MARK2, leading to inhibit MARK2 independently of kinase activity. Interacts with RHOD and RHOH.

ID gène: 57144

UniProt: P24158