MICU1 anticorps (AA 1-250) (HRP)

N° du produit ABIN6988022

L’anticorps Souris Monoclonal anti-MICU1 a été validé pour WB. Il convient pour détecter MICU1 dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour MICU1 anticorps (AA 1-250) (HRP) (ABIN6988022)

Antigène: MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))

Reactivité: Humain, Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MICU1 est conjugé à/à la HRP

Application: Western Blotting (WB)

Clone: 1H8

Détail du produit anti-MICU1 anticorps (HRP)

Épitope: AA 1-250

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein G.

Immunogène: Recombinant human CBARA1 Protein (1-250/476)

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur MICU1

Antigène: MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))

Autre désignation: CBARA1/MICU1

Sujet:

Synonyms: Mitochondrial Calcium Uptake 1, Calcium-Binding Atopy-Related Autoantigen 1, Atopy-Related Autoantigen CALC, Ara CALC, CBARA1, CALC, Calcium Binding Atopy-Related Autoantigen 1, Calcium Uptake Protein 1, Mitochondrial, Allergen Hom S 4, EFHA3, MPXPS, MICU1_HUMAN,

Background: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).

ID gène: 10367

UniProt: Q9BPX6