Cyclin E2 anticorps

N° du produit ABIN6989714

L’anticorps Lapin Monoclonal anti-Cyclin E2 a été validé pour WB, IHC (p), FACS et IF (cc). Il convient pour détecter Cyclin E2 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Cyclin E2 anticorps (ABIN6989714)

Antigène: Cyclin E2 (CCNE2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Cyclin E2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 2B1

Détail du produit anti-Cyclin E2 anticorps

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant human Cyclin E2 protein, around C-terminal 100aa.

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Cyclin E2

Antigène: Cyclin E2 (CCNE2)

Autre désignation: Cyclin E2

Sujet:

Synonyms: Cyclin E2 phospho T392, p-Cyclin E2 phospho T392,CCN E2, CCNE 2, CCNE2, CCNE2 protein, CYC E2, CYCE 2, CYCE2, CyclinE2, G1/S-specic cyclin E2, G1/S-specic cyclin E2.

Background: The human Cyclin E2 gene encodes a 404 amino acid protein that is most closely related to Cyclin E. Cyclin E2 mRNA levels peaks at the G1 / S transition. Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27 (Kip1) and p21 (Cip1). Cyclin E2 / Cdk2 phosphorylates histone H1 in vitro. G1 cyclin E controls the initiation of DNA synthesis by activating CDK2. Abnormally high levels of cyclin E expression have frequently been observed in human cancers. Unlike Cyclin E1, which is expressed in great majority of proliferating normal and neoplastically transformed cells, Cyclin E2 levels are low to undetectable in non transformed cells and increase significantly in neoplasm derived cells.

ID gène: 9134

UniProt: O96020

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases