RAC1+CDC42 (pSer71) anticorps

N° du produit ABIN6989963

L’anticorps anti-RAC1+CDC42 Monoclonal Lapin est utilisé pour la détection de RAC1+CDC42 dans des échantillons de Humain. Il a été validé pour WB, IHC, IF (cc) et IHC (p).

Aperçu rapide pour RAC1+CDC42 (pSer71) anticorps (ABIN6989963)

Antigène: RAC1+CDC42

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 5H1

Détail du produit

Épitope: pSer71

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: Synthetic phospho-Peptide corresponding to residues surrounding Ser71 of human CDC42.

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC()

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détail du antigène

Antigène: RAC1+CDC42

Sujet:

Synonyms: CDC42Hs antibody, Cell division cycle 42 antibody, G25K antibody, MIG5 antibody, Migration inducing gene 5 antibody, p21 Rac1 antibody, Ras like protein TC25 antibody, Small GTP binding protein Cdc42 antibody, TC25 antibody

Background: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013].

ID gène: 998

UniProt: P60953

Pathways: Signalisation WNT