PUMA anticorps (AA 76-170)
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- Antigène Voir toutes PUMA (BBC3) Anticorps
- PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
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Épitope
- AA 76-170
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Reactivité
- Humain, Rat, Souris
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp PUMA est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Purification
- PUMA Monoclonal Antibody is immunoaffinity chromotography purified IgG.
- Immunogène
- Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
- Clone
- 2A9G5
- Isotype
- IgG1
- Top Product
- Discover our top product BBC3 Anticorps primaire
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anti-BCL2 Binding Component 3 (BBC3) antibody
BBC3 Reactivité: Humain WB, IHC, IF Hôte: Lapin Monoclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibodyBBC3 Reactivité: Humain WB, ICC, IF Hôte: Lapin Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 131-180) antibodyBBC3 Reactivité: Humain, Rat, Porc WB, ELISA, IP, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 119-154) antibodyBBC3 Reactivité: Humain WB, FACS, IHC (p), IF Hôte: Lapin Polyclonal RB01353 unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 119-154) antibodyBBC3 Reactivité: Humain WB, ELISA, IHC, FACS, IF Hôte: Lapin Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (N-Term) antibodyBBC3 Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibody (PE)BBC3 Reactivité: Humain WB, ICC, IF Hôte: Lapin Polyclonal PE
anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibody (PerCP)BBC3 Reactivité: Humain WB, ICC, IF Hôte: Lapin Polyclonal PerCP
anti-BCL2 Binding Component 3 (BBC3) (N-Term) antibody (Biotin)BBC3 Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal Biotin
anti-BCL2 Binding Component 3 (BBC3) (BH3 Domain), (C-Term) antibodyBBC3 Reactivité: Humain, Souris WB, FACS, IHC (p), IF, EIA Hôte: Lapin Polyclonal unconjugated
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- Indications d'application
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PUMA antibody can be used for detection of PUMA by Western blot at 2.5 to 5 μ,g/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PUMA Monoclonal Antibody is supplied in PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- PUMA monoclonal antibody can be stored at -20°C, stable for one year.
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- Antigène
- PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
- Autre désignation
- PUMA (BBC3 Produits)
- Synonymes
- anticorps BBC3, anticorps Puma, anticorps JFY-1, anticorps JFY1, anticorps PUMA, anticorps PUMA/JFY1, anticorps BCL2 binding component 3, anticorps Bcl-2 binding component 3, anticorps BBC3, anticorps Bbc3, anticorps bbc3
- Sujet
- PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα, and PUMAβ,. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
- ID gène
- 27113
- UniProt
- Q9BXH1
- Pathways
- Signalisation p53, Positive Regulation of Endopeptidase Activity
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