ORAI3 anticorps (C-Term)

N° du produit ABIN6990192

Cet anticorps anti-ORAI3 Monoclonal Souris (Clone 1B4F1) (ABIN6990192) détecte spécifiquement ORAI3 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain et Rat.

Aperçu rapide pour ORAI3 anticorps (C-Term) (ABIN6990192)

Antigène: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ORAI3 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 1B4F1

Détail du produit anti-ORAI3 anticorps

Épitope: C-Term

Purification: ORAI3 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Immunogène: A 19 amino acid synthetic peptide from near the carboxy terminus of human ORAI3.

Isotype: IgG2b

Information d'application

Indications d'application: ORAI3 antibody can be used for detection of ORAI3 by Western blot at 2 μ,g/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ORAI3 Monoclonal Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: ORAI3 monoclonal antibody can be stored at -20°C, stable for one year.

Détails sur ORAI3

Antigène: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Autre désignation: ORAI3

Sujet: ORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE, these may represent post-translationally modified ORAI 3.

ID gène: 93129

UniProt: Q9BRQ5