IRAK2 anticorps (C-Term)

N° du produit ABIN6990294

Cet anticorps anti-IRAK2 est un anticorps Lapin Polyclonal détectant IRAK2 dans WB, ELISA, ICC et IF. Adapté pour Humain.

Aperçu rapide pour IRAK2 anticorps (C-Term) (ABIN6990294)

Antigène: IRAK2 (Interleukin-1 Receptor-Associated Kinase 2 (IRAK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRAK2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-IRAK2 anticorps

Épitope: AA 530-580, C-Term

Specificité: Anti-IRAK2 has no cross response to IRAK.

Purification: IRAK-2 Antibody is affinity chromatography purified via peptide column.

Immunogène: IRAK2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human IRAK2. The immunogen is located within amino acids 530 - 580 of IRAK-2.

Isotype: IgG

Information d'application

Indications d'application: IRAK-2 antibody can be used for detection of IRAK2 by Western blot at 2 μ,g/mL. A 65 kDa band should be detected. This polyclonal antibody can also detect IRAK2 by immunocytochemistry at 2 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: IRAK-2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: IRAK-2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur IRAK2

Antigène: IRAK2 (Interleukin-1 Receptor-Associated Kinase 2 (IRAK2))

Autre désignation: IRAK-2

Sujet: IRAK-2 Antibody: The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-κ,B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-κ,B activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-κ,B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. IRAK2 is expressed in a variety of human tissues.

Poids moléculaire: 65 kDa

ID gène: 3656

UniProt: O43187

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades