IL1RAP anticorps (C-Term)

N° du produit ABIN6990297

Détail du produit anti-IL1RAP anticorps

Antigène: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL1RAP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: This polyclonal antibody has no cross activity to other members in the IL-1 receptor family.

Purification: IL-1RAcP Antibody is affinity chromatography purified via peptide column.

Immunogène: IL-1RAcP antibody was raised against a 16 amino acid peptide near the carboxy terminus of human IL-1RAcP. The immunogen is located within the last 50 amino acids of IL-1RAcP.

Isotype: IgG

Information d'application

Indications d'application: IL-1RAcP antibody can be used for detection of IL-1RAcP by Western blot at 1 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 2 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-1RAcP Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: IL-1RAcP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur IL1RAP

Antigène: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Autre désignation: IL-1RAcP (IL1RAP Produits)

Synonymes: anticorps IL1RAP, anticorps il-1racp, anticorps il-racp, anticorps il1r3, anticorps C3orf13, anticorps IL-1RAcP, anticorps IL1R3, anticorps 6430709H04Rik, anticorps AI255955, anticorps AV239853, anticorps IL-1RAcp, anticorps Il1racpb, anticorps interleukin 1 receptor accessory protein, anticorps IL1RAP, anticorps il1rap, anticorps il-1racp, anticorps Il1rap

Sujet: IL-1RAcP Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-κ,B inducing kinae (NIK) and of NF-κ,B, recruits to the IL-1R complex through IL-1RAcP. IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP. Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.

Poids moléculaire: Predicted: 63 kDa

Observed: 66 kDa

ID gène: 3556

NCBI Accession: NP_001161401

UniProt: Q9NPH3

Pathways: Signalisation NF-kappaB, Growth Factor Binding