GOPC anticorps (AA 240-290)

N° du produit ABIN6990582

Cet anticorps anti-GOPC est un anticorps Lapin Polyclonal détectant GOPC dans WB, ELISA, IF et IHC (p). Adapté pour Humain et Souris.

Aperçu rapide pour GOPC anticorps (AA 240-290) (ABIN6990582)

Antigène: GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GOPC est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-GOPC anticorps

Épitope: AA 240-290

Purification: PIST Antibody is affinity chromatography purified via peptide column.

Immunogène: PIST antibody was raised against a 17 amino acid synthetic peptide from near the center of human PIST. The immunogen is located within amino acids 240 - 290 of PIST.

Isotype: IgG

Information d'application

Indications d'application: PIST antibody can be used for the detection of PIST by Western blot at 1 - 4 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PIST Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: PIST antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur GOPC

Antigène: GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))

Autre désignation: PIST

Sujet: PIST Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). PIST, a PDZ-containing protein, was discovered in a yeast two-hybrid system as a binding partner to Beclin-1, a Bcl-2-interacting protein homologous to the yeast autophagy gene apg6. Experiments with mutant PIST proteins lacking the PDZ domain showed that PIST interaction with Beclin-1 through its coiled-coil domain can modulate Beclin-1 activity and suggest that PIST interactions with other proteins through its PDZ domain may regulate the activity of PIST and Beclin-1.

ID gène: 57120

UniProt: Q9HD26

Pathways: Maintenance of Protein Location, Asymmetric Protein Localization