LSD1 anticorps (AA 140-190)

N° du produit ABIN6990620

Détail du produit anti-LSD1 anticorps

Antigène: LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Épitope: AA 140-190

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LSD1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: LSD1 Antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-LSD1 antibody was raised against a peptide corresponding to 16 amino acids near the center of human LSD1. The immunogen is located within amino acids 140-190 of LSD1.

Isotype: IgG

Information d'application

Indications d'application: WB: 0.2 - 2 μ,g/mL, IHC-P: 2 μ,g/mL, IF: 20 μ,g/mL

Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: LSD1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: LSD1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur LSD1

Antigène: LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Autre désignation: LSD1 (KDM1A Produits)

Synonymes: anticorps AOF2, anticorps BHC110, anticorps KDM1, anticorps LSD1, anticorps 1810043O07Rik, anticorps AA408884, anticorps Aof2, anticorps D4Ertd478e, anticorps Kdm1, anticorps Lsd1, anticorps mKIAA0601, anticorps DKFZp459N2450, anticorps RGD1562975, anticorps aof2, anticorps kdm1, anticorps wu:fb82e06, anticorps wu:fc51a02, anticorps wu:fj36a05, anticorps wu:fj66b06, anticorps KDM1A, anticorps lsd1, anticorps xLSD1, anticorps AtLSD1, anticorps F9F13.30, anticorps F9F13_30, anticorps LESION SIMULATING DISEASE, anticorps LESION SIMULATING DISEASE 1, anticorps lysine demethylase 1A, anticorps lysine (K)-specific demethylase 1A, anticorps lysine (K)-specific demethylase 1a, anticorps LSD1 zinc finger family protein, anticorps KDM1A, anticorps Kdm1a, anticorps kdm1a, anticorps LSD1

Sujet: LSD1 Antibody: Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction. Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription. LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation. Experiments have shown that CoREST, a SANT domain-containing corepressor acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein, inhibits CoREST/LSD1 activity in vitro. LSD1-mediated histone demethylation thus may have significant effects on gene expression.

Poids moléculaire: Predicted: 93kD

Observed: 110 kD kDa

ID gène: 23028

NCBI Accession: NP_001009999

UniProt: O60341

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, L'effet Warburg