SLUG anticorps (AA 90-140)

N° du produit ABIN6990683

L’anticorps anti-SLUG Polyclonal Lapin est utilisé pour la détection de SLUG dans des échantillons de Humain et Souris. Il a été validé pour WB, ELISA et IF.

Aperçu rapide pour SLUG anticorps (AA 90-140) (ABIN6990683)

Antigène: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLUG est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-SLUG anticorps

Épitope: AA 90-140

Specificité: This Slug antibody is predicted to not cross-react with Snail.

Purification: Slug Antibody is affinity chromatography purified via peptide column.

Immunogène: Slug antibody was raised against a 13 amino acid synthetic peptide from near the center of human Slug. The immunogen is located within amino acids 90 - 140 of Slug.

Isotype: IgG

Information d'application

Indications d'application: Slug antibody can be used for detection of Slug by Western blot at 0.5 μ,g/mL. Antibody can also be used for immunofluorescence starting at 20 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Slug Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Slug antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SLUG

Antigène: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Autre désignation: Slug

Sujet: Slug Antibody: Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.

Poids moléculaire: Predicted: 29 kDa

Observed: 30 kDa

ID gène: 6591

UniProt: O43623