Kdm6b anticorps (C-Term)

N° du produit ABIN6990705

Cet anticorps anti-Kdm6b est un anticorps Lapin Polyclonal détectant Kdm6b dans WB, ELISA, IF et ICC. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Kdm6b anticorps (C-Term) (ABIN6990705)

Antigène: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Kdm6b est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-Kdm6b anticorps

Épitope: AA 1370-1420, C-Term

Specificité: This antibody is specific for JMJD3 and will not recognize other JMJD proteins.

Purification: JMJD3 Antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-JMJD3 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human JMJD3. The immunogen is located within amino acids 1370-1420 of JMJD3.

Isotype: IgG

Information d'application

Indications d'application: WB: 0.25-4 μ,g/mL, ICC: 2.5 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in human, mouse and rat samples, Immunocytochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: JMJD3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: JMJD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur Kdm6b

Antigène: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Autre désignation: JMJD3

Sujet: JMJD3 Antibody: The Jumonji domain-containing protein 3 (JMJD3) functions as a trimethylation-specific demethylase, converting the trimethylated histone H3 Lys27 residue to the dimethylated form, and is thought to also function as a transcriptional repressor. JMJD3 plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. JMJD3 can also interact with and demethylate p53, resulting in its stabilization and localization to the nucleus in mouse embryo fibroblasts during neural stem cell differentiation.

Poids moléculaire: Predicted: 180

Observed: 180 kD kDa

ID gène: 23135

UniProt: O15054

Pathways: L'effet Warburg