FYB anticorps (N-Term)

N° du produit ABIN6990773

Détail du produit anti-FYB anticorps

Antigène: FYB (FYN-Binding Protein (FYB))

Épitope: AA 60-110, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FYB est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Purification: ADAP Antibody is affinity chromatography purified via peptide column.

Immunogène: ADAP antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human ADAP. The immunogen is located within amino acids 60 - 110 of ADAP.

Isotype: IgG

Information d'application

Indications d'application: ADAP antibody can be used for detection of ADAP by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ADAP Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ADAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur FYB

Antigène: FYB (FYN-Binding Protein (FYB))

Autre désignation: ADAP (FYB Produits)

Synonymes: anticorps fyb, anticorps ADAP, anticorps PRO0823, anticorps SLAP-130, anticorps B630013F22Rik, anticorps FYB-120/130, anticorps Slap130, anticorps p120/130, anticorps p120/p130, anticorps RGD1563421, anticorps FYN-binding protein, anticorps FYN binding protein 1, anticorps FYN binding protein, anticorps fyb, anticorps FYB1, anticorps Fyb, anticorps Fyb1

Sujet: ADAP Antibody: The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-κ,B family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.

ID gène: 2533

NCBI Accession: NP_001456

UniProt: O15117

Pathways: TCR Signaling, Protein targeting to Nucleus