BRE anticorps (N-Term)

N° du produit ABIN6990794

L’anticorps Lapin Polyclonal anti-BRE a été validé pour WB, ELISA, IF et IHC (p). Il convient pour détecter BRE dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour BRE anticorps (N-Term) (ABIN6990794)

Antigène: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRE est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-BRE anticorps

Épitope: N-Term

Purification: BRCC45 Antibody is affinity chromatography purified via peptide column.

Immunogène: BRCC45 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human BRCC45. The immunogen is located within the last 50 amino acids of BRCC45.

Isotype: IgG

Information d'application

Indications d'application: BRCC45 antibody can be used for detection of BRCC45 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: BRCC45 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: BRCC45 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur BRE

Antigène: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Autre désignation: BRCC45

Sujet: BRCC45 Antibody: BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.

ID gène: 9577

NCBI Accession: NP_004890

UniProt: Q9NXR7

Pathways: Positive Regulation of Response to DNA Damage Stimulus