CNOT4 anticorps (N-Term)

N° du produit ABIN6990985

Cet anticorps Lapin Polyclonal détecte spécifiquement CNOT4 dans WB et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour CNOT4 anticorps (N-Term) (ABIN6990985)

Antigène: CNOT4 (CCR4-NOT Transcription Complex Subunit 4 (CNOT4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CNOT4 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CNOT4 anticorps

Épitope: AA 70-120, N-Term

Purification: CNOT4 Antibody is affinity chromatography purified via peptide column.

Immunogène: CNOT4 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of the human CNOT4. The immunogen is located within amino acids 70 - 120 of CNOT4.

Isotype: IgG

Information d'application

Indications d'application: CNOT4 antibody can be used for detection of CNOT4 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: CNOT4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: CNOT4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur CNOT4

Antigène: CNOT4 (CCR4-NOT Transcription Complex Subunit 4 (CNOT4))

Autre désignation: CNOT4

Sujet: CNOT4 Antibody: CNOT4 is a component of the CCR4-NOT transcription complex, a complex that is implicated in the repression of RNA polymerase II transcription. In the CCR4-NOT complex, CNOT4 acts as an E3 ubiquitin-protein ligase and interacts with a subset of E2 ubiquitin-conjugating enzymes through a unique C4C4 RING domain. This E3 ligase activity was shown to be dependent on the selective and specific interaction with the ubiquitin conjugating enzyme UbcH5B. In yeast, mutations in CNOT4 that prevented its interaction with the UbcH5B homolog UBC4 caused increased sensitivity to hydroxyurea, heat shock, and hygromycin B, suggesting that CNOT4 and UbcH5B are involved in stress response in vivo. Multiple isoforms of CNOT4 are known to exist.

ID gène: 4850

NCBI Accession: NP_037448

UniProt: O95628