DISP2 anticorps (N-Term)

N° du produit ABIN6991015

Cet anticorps Lapin Polyclonal détecte spécifiquement DISP2 dans ELISA et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour DISP2 anticorps (N-Term) (ABIN6991015)

Antigène: DISP2 (Dispatched Homolog 2 (DISP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DISP2 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-DISP2 anticorps

Épitope: AA 110-160, N-Term

Specificité: DISP2 antibody is human specific. At least two isoforms of Disp2 are known to exist. DISP2 antibody is predicted to not cross-react with Disp1 or Disp3.

Purification: DISP2 Antibody is affinity chromatography purified via peptide column.

Immunogène: DISP2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DISP2. The immunogen is located within amino acids 110 - 160 of DISP2.

Isotype: IgG

Information d'application

Indications d'application: DISP2 antibody can be used for detection of DISP2 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: DISP2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: DISP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur DISP2

Antigène: DISP2 (Dispatched Homolog 2 (DISP2))

Autre désignation: DISP2

Sujet: DISP2 Antibody: DISP2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants.

ID gène: 85455

UniProt: A7MBM2

Pathways: Signalisation Hedgehog