CDIP1 anticorps (AA 70-120)

N° du produit ABIN6991072

Cet anticorps Lapin Polyclonal détecte spécifiquement CDIP1 dans WB, ELISA, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour CDIP1 anticorps (AA 70-120) (ABIN6991072)

Antigène: CDIP1 (LITAF-Like Protein (CDIP1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDIP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-CDIP1 anticorps

Épitope: AA 70-120

Purification: CDIP Antibody is affinity chromatography purified via peptide column.

Immunogène: CDIP antibody was raised against a 19 amino acid synthetic peptide near the center of human CDIP. The immunogen is located within amino acids 70 - 120 of CDIP.

Isotype: IgG

Information d'application

Indications d'application: CDIP antibody can be used for detection of CDIP by Western blot at 0.25 - 0.5 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: CDIP Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: CDIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur CDIP1

Antigène: CDIP1 (LITAF-Like Protein (CDIP1))

Autre désignation: CDIP

Sujet: CDIP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death, loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.

ID gène: 29965

NCBI Accession: NP_037531

UniProt: Q9H305