Norrie Disease (Pseudoglioma) anticorps (N-Term)

N° du produit ABIN6991095

Cet anticorps anti-Norrie Disease (Pseudoglioma) est un anticorps Lapin Polyclonal détectant Norrie Disease (Pseudoglioma) dans WB, ELISA et ICC. Adapté pour Humain.

Aperçu rapide pour Norrie Disease (Pseudoglioma) anticorps (N-Term) (ABIN6991095)

Antigène: Norrie Disease (Pseudoglioma) (NDP)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Norrie Disease (Pseudoglioma) est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-Norrie Disease (Pseudoglioma) anticorps

Épitope: N-Term

Purification: Norrin Antibody is affinity chromatography purified via peptide column.

Immunogène: Norrin antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human Norrin. The immunogen is located within the first 50 amino acids of Norrin.

Isotype: IgG

Information d'application

Indications d'application: Norrin antibody can be used for detection of Norrin by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Norrin Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Norrin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur Norrie Disease (Pseudoglioma)

Antigène: Norrie Disease (Pseudoglioma) (NDP)

Autre désignation: Norrin

Sujet: Norrin Antibody: Norrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/beta-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina, transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/beta-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.

ID gène: 4693

NCBI Accession: NP_000257

UniProt: Q00604

Pathways: Sensory Perception of Sound