ADAM10 anticorps (C-Term)

N° du produit ABIN6991127

L’anticorps anti-ADAM10 Polyclonal Lapin est utilisé pour la détection de ADAM10 dans des échantillons de Humain. Il a été validé pour WB, ELISA, ICC et IF.

Aperçu rapide pour ADAM10 anticorps (C-Term) (ABIN6991127)

Antigène: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADAM10 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-ADAM10 anticorps

Épitope: C-Term

Purification: ADAM10 Antibody is affinity chromatography purified via peptide column.

Immunogène: ADAM10 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ADAM10. The immunogen is located within the last 50 amino acids of ADAM10.

Isotype: IgG

Information d'application

Indications d'application: ADAM10 can be used for detection of ADAM10 by Western blot at 1 - 2 μ,g/mL. This polyclonal antibody can also detect ADAM10 by immunohistochemistry at 2 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ADAM10 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ADAM10 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur ADAM10

Antigène: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Autre désignation: ADAM10

Sujet: ADAM10 Antibody: Proinflammatory cytokine tumor necrosis factor-alpha (TNF-α,) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-α, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-α, notch and its ligand delta. The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.

Poids moléculaire: 85 kDa

ID gène: 102

NCBI Accession: NP_001101

UniProt: O14672

Pathways: Signalisation Notch, EGFR Signaling Pathway