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THEM4 anticorps (AA 60-110)

THEM4 Reactivité: Humain, Souris, Rat WB, ELISA, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6991139
  • Antigène Voir toutes THEM4 Anticorps
    THEM4 (Thioesterase Superfamily Member 4 (THEM4))
    Épitope
    • 2
    • 1
    • 1
    • 1
    AA 60-110
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 3
    • 2
    Lapin
    Clonalité
    • 5
    Polyclonal
    Conjugué
    • 5
    Cet anticorp THEM4 est non-conjugé
    Application
    • 5
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    The additional higher molecular weight bands seen in the immunoblot may represent post-translationally modified TMEM4.
    Purification
    THEM4 Antibody is affinity chromatography purified via peptide column.
    Immunogène
    THEM4 antibody was raised against an 18 amino acid synthetic peptide near the center of human THEM4. The immunogen is located within amino acids 60 - 110 of THEM4.
    Isotype
    IgG
    Top Product
    Discover our top product THEM4 Anticorps primaire
  • Indications d'application
    THEM4 antibody can be used for detection of THEM4 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    THEM4 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    THEM4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    THEM4 (Thioesterase Superfamily Member 4 (THEM4))
    Autre désignation
    THEM4 (THEM4 Produits)
    Synonymes
    anticorps THEM4, anticorps CTMP, anticorps 2700077M13Rik, anticorps 4921507I02Rik, anticorps RGD1304723, anticorps thioesterase superfamily member 4, anticorps thioesterase superfamily member 4 L homeolog, anticorps THEM4, anticorps them4, anticorps Them4, anticorps them4.L
    Sujet
    THEM4 Antibody: THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.
    ID gène
    117145
    NCBI Accession
    NP_444283
    UniProt
    Q5T1C6
    Pathways
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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