TMEM38B anticorps (C-Term)

N° du produit ABIN6991240

Détail du produit anti-TMEM38B anticorps

Antigène: TMEM38B (Transmembrane Protein 38B (TMEM38B))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMEM38B est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: TMEM38B Antibody is affinity chromatography purified via peptide column.

Immunogène: TMEM38B antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TMEM38B. The immunogen is located within the last 50 amino acids of TMEM38B.

Isotype: IgG

Information d'application

Indications d'application: TMEM38B antibody can be used for detection of TMEM38B by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TMEM38B Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TMEM38B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TMEM38B

Antigène: TMEM38B (Transmembrane Protein 38B (TMEM38B))

Autre désignation: TMEM38B (TMEM38B Produits)

Synonymes: anticorps zgc:55815, anticorps tricb, anticorps tric-b, anticorps MGC83592, anticorps DKFZp469C0220, anticorps C9orf87, anticorps D4Ertd89e, anticorps OI14, anticorps TRIC-B, anticorps TRICB, anticorps bA219P18.1, anticorps 1600017F22Rik, anticorps AA437809, anticorps AV051057, anticorps mg33b, anticorps RGD1305703, anticorps transmembrane protein 38B, anticorps transmembrane protein 38B L homeolog, anticorps tmem38b, anticorps TMEM38B, anticorps tmem38b.L, anticorps Tmem38b

Sujet: TMEM38B Antibody: TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure, the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.

ID gène: 55151

NCBI Accession: NP_060582

UniProt: Q9NVV0