TMEM38B anticorps (Cytoplasmic Loop, Intracellular)

N° du produit ABIN7885622

Cet anticorps anti-TMEM38B Polyclonal Lapin (ABIN7885622) détecte spécifiquement TMEM38B dans WB, IHC et IC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TMEM38B anticorps (Cytoplasmic Loop, Intracellular) (ABIN7885622)

Antigène: TMEM38B (Transmembrane Protein 38B (TMEM38B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMEM38B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC)

Classe de qualité: Carrier-free

Détail du produit anti-TMEM38B anticorps

Épitope: AA 116-126, Cytoplasmic Loop, Intracellular

Fonction: A Rabbit Polyclonal Antibody to TRIC-B Channel

Homologie: Mouse,human - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)GMKEVTRTWKIVG, corresponding to amino acid residues 116-126 of rat TRIC-B

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:200

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237524)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur TMEM38B

Antigène: TMEM38B (Transmembrane Protein 38B (TMEM38B))

Autre désignation: Trimeric intracellular cation channel type B

Sujet:

Synonyms: Trimeric intracellular cation channel type B, Transmembrane protein 38B

Description: Intracellular Ca2+ levels are important in proper cellular functions and have prominent roles in various cell signaling pathways and are crucial for muscle contractions. Indeed, an important step leading to muscle contraction is the massive release of Ca2+ ions from the endoplasmic/sarcoplasmic reticulum (ER/SR) to the cytosol. A battery of results suggest that specific K+ channels are important to counteract the Ca2+ outflow in order to neutralize the negative potential created by the movement of Ca2+ ions. It is believed that TRIC channels are responsible for neutralizing this negative potential1,2.Trimeric intracellular cation-specific (TRIC) channels are critical for proper management of intracellular stores. TRIC-A and TRIC-B both belong to this family and are both permeable to monovalent ions with a preference for K+ 3. Both channels are localized to the ER/SR membrane. Each TRIC subunit contains three transmembrane domains, a cytoplasmic C-terminus and a luminal N-terminus. Functional entities are formed by homotrimerizarion4. The activity of TRIC-A is regulated by voltage whereas that of TRIC-B can be regulated by different mechanisms3.Knockout studies of these channels have shown that TRIC-A knockout mice are viable while those of TRIC-B die at the neonatal stage5.TRIC-A is mostly expressed in excitable tissues like the brain and muscle while TRIC-B is ubiquitously expressed.

ID gène: 362521

UniProt: Q68FV1