AXIN2 anticorps (C-Term)
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- Antigène Voir toutes AXIN2 Anticorps
- AXIN2 (Axin 2 (AXIN2))
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Épitope
- AA 780-830, C-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp AXIN2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- AXIN2 antibody is predicted to not cross-react with AXIN1. At least four isoforms of AXIN2 are known to exist, this antibody will recognize all four.
- Purification
- AXIN2 Antibody is affinity chromatography purified via peptide column.
- Immunogène
- AXIN2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human AXIN2. The immunogen is located within amino acids 780 - 830 of AXIN2.
- Isotype
- IgG
- Top Product
- Discover our top product AXIN2 Anticorps primaire
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- Indications d'application
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AXIN2 antibody can be used for detection of AXIN2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse and rat samples and Immunofluorescence in mouse and rat samples. All other applications and species not yet tested. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- AXIN2 Antibody is supplied in PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,4 °C
- Stockage commentaire
- AXIN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Antigène
- AXIN2 (Axin 2 (AXIN2))
- Autre désignation
- AXIN2 (AXIN2 Produits)
- Synonymes
- anticorps AXIL, anticorps ODCRCS, anticorps axil, anticorps wu:fb37c08, anticorps zgc:111942, anticorps axin-2, anticorps xarp, anticorps MGC81576, anticorps arp-A, anticorps axin2, anticorps Axi1, anticorps Axil, anticorps Conductin, anticorps axin 2, anticorps axin 2 (conductin, axil), anticorps axin 2 (conductin, axil) S homeolog, anticorps AXIN2, anticorps axin2, anticorps axin2.S, anticorps Axin2
- Sujet
- AXIN2 Antibody: Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
- Poids moléculaire
- 85, 93 kDa
- ID gène
- 8313
- UniProt
- Q9Y2T1
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
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