LRRTM3 anticorps (C-Term)

N° du produit ABIN6991483

Cet anticorps Lapin Polyclonal détecte spécifiquement LRRTM3 dans WB, ELISA, IF et IHC (p). Il présente une réactivité envers Souris, Humain et Rat.

Aperçu rapide pour LRRTM3 anticorps (C-Term) (ABIN6991483)

Antigène: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRRTM3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-LRRTM3 anticorps

Épitope: C-Term

Specificité: At least two isoforms of LRRTM3 are known to exist, this antibody will only detect the larger isoform.

Purification: LRRTM3 Antibody is affinity chromatography purified via peptide column.

Immunogène: LRRTM3 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human LRRTM3. The immunogen is located within the last 50 amino acids of LRRTM3.

Isotype: IgG

Information d'application

Indications d'application: LRRTM3 antibody can be used for detection of LRRTM3 by Western blot at 0.5 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: LRRTM3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: LRRTM3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur LRRTM3

Antigène: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Autre désignation: LRRTM3

Sujet: LRRTM3 Antibody: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the Abeta42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma Abeta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.

ID gène: 347731

NCBI Accession: NP_821079

UniProt: Q86VH5

Pathways: Synaptic Membrane