DYRK1A anticorps (C-Term)

N° du produit ABIN6991514

L’anticorps anti-DYRK1A Polyclonal Lapin est utilisé pour la détection de DYRK1A dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA et ICC.

Aperçu rapide pour DYRK1A anticorps (C-Term) (ABIN6991514)

Antigène: DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DYRK1A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-DYRK1A anticorps

Épitope: C-Term

Specificité: Multiple isoforms of DYRK1A are known to exist. DYRK1A antibody will not cross-react with other DYRK family members

Purification: DYRK1A Antibody is affinity chromatography purified via peptide column.

Immunogène: DYRK1A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human DYRK1A. The immunogen is located within the last 50 amino acids of DYRK1A.

Isotype: IgG

Information d'application

Indications d'application: DYRK1A antibody can be used for detection of DYRK1A by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: DYRK1A Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: DYRK1A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur DYRK1A

Antigène: DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))

Autre désignation: DYRK1A

Sujet: DYRK1A Antibody: DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family and is thought to be involved in neuronal differentiation, neurodegenerative diseases, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. DYRK1A phosphorylates several transcription factors such as p53, leading to inhibition of embryonic neuronal cell proliferation. DYRK1A associates with multiple proteins, including SPRED1 and SPRED2, this association appears to inhibit the phosphorylation activity of DYRK1A. Recent evidence also suggests that DYRK1A may be involved in the replication of HIV-1.

Poids moléculaire: Predicted: 84 kDa

Observed: 90 kDa

ID gène: 1859

NCBI Accession: NP_001387

UniProt: Q13627

Pathways: Mitotic G1-G1/S Phases