MSI2 anticorps (N-Term)

N° du produit ABIN6991532

L’anticorps Lapin Polyclonal anti-MSI2 a été validé pour WB, ELISA, IF, IHC (p) et ICC. Il convient pour détecter MSI2 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MSI2 anticorps (N-Term) (ABIN6991532)

Antigène: MSI2 (Musashi Homolog 2 (MSI2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MSI2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Détail du produit anti-MSI2 anticorps

Épitope: AA 30-80, N-Term

Specificité: MSI2 antibody is predicted to not cross-react with MSI1. Multiple isoforms of MSI2 are known to exist.

Purification: MSI2 Antibody is affinity chromatography purified via peptide column.

Immunogène: MSI2 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human MSI2. The immunogen is located within amino acids 30 - 80 of MSI2.

Isotype: IgG

Information d'application

Indications d'application: MSI2 antibody can be used for detection of MSI2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL and immunocytochemistry starting at 5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples, Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: MSI2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: MSI2 antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur MSI2

Antigène: MSI2 (Musashi Homolog 2 (MSI2))

Autre désignation: MSI2

Sujet: MSI2 Antibody: Musashi2 (MSI2) is an RNA-binding protein that is highly expressed in precursor cells in the ventricular and subventricular zones of the developing mammalian CNS. Like the related MSI1, MSI2 has been suggested to be involved stem cell production and maintenance. MSI2 is the predominant MSI protein in hematopoietic stem cells, and its knockdown leads to reduced engraftment and depletion in vivo. Expression levels of MSI2 are elevated in myeloid leukemia cells lines, and MSI2 appears to cooperate with BCR-ABL1 to induce an aggressive leukemia, the level of MSI2 directly correlates with decreased survival in patients. MSI2 negatively regulates the asymmetric cell fate determinant NUMB, suggesting that this signaling pathway may provide future targets for future therapies.

ID gène: 124540

UniProt: Q96DH6