NKX2-1 anticorps (N-Term)

N° du produit ABIN6991652

Détail du produit anti-NKX2-1 anticorps

Antigène: NKX2-1 (NK2 Homeobox 1 (NKX2-1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NKX2-1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: NKX2-1 antibody is predicted to not cross-react with other NK2 homeobox family members. At least three isoforms of NKX2-1 are known to exist, this antibody will detect all three.

Purification: NKX2-1 Antibody is affinity chromatography purified via peptide column.

Immunogène: NKX2-1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human NKX2-1. The immunogen is located within the first 50 amino acids of NKX2-1.

Isotype: IgG

Information d'application

Indications d'application: NKX2-1 antibody can be used for detection of NKX2-1 by Western blot at 0.25 - 0.5 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: NKX2-1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: NKX2-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur NKX2-1

Antigène: NKX2-1 (NK2 Homeobox 1 (NKX2-1))

Autre désignation: NKX2-1 (NKX2-1 Produits)

Synonymes: anticorps BCH, anticorps BHC, anticorps NK-2, anticorps NKX2.1, anticorps NKX2A, anticorps TEBP, anticorps TITF1, anticorps TTF-1, anticorps TTF1, anticorps titf1-A, anticorps Xnkx-2.1, anticorps NKX2-1, anticorps LOC100227803, anticorps AV026640, anticorps Nkx2.1, anticorps T/EBP, anticorps Titf1, anticorps Ttf-1, anticorps nk2.1a, anticorps nkx2.1, anticorps nkx2.4a, anticorps titf1, anticorps titf1a, anticorps NK2 homeobox 1, anticorps NK2 homeobox 1 L homeolog, anticorps NK2 homeobox 4b, anticorps NKX2-1, anticorps nkx2-1.L, anticorps Nkx2-1, anticorps nkx2.4b

Sujet: NKX2-1 Antibody: NKX2-1 (NK2 homeobox 1) has been identified as a thyroid-specific transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin and thyrotropin receptor. NKX2-1 is crucial in the maintenance of the thyroid differentiation phenotype and morphogenesis. It contains one homeobox DNA-binding domain. NKX2-1 also may play a role in lung development and surfactant homeostasis. Mutations and deletions in this gene are associated with benign hereditary chorea, congenital hypothyroidism, neonatal respiratory distress, and may be associated with thyroid cancer. NKX2-1 has been suggested to be a candidate suppressor of malignant progression.

Poids moléculaire: Predicted: 46 kDa

Observed: 41, 45 kDa

ID gène: 7080

UniProt: P43699

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Glucan Metabolic Process, Feeding Behaviour