TET2 anticorps (N-Term)

N° du produit ABIN6991708

Cet anticorps Lapin Polyclonal détecte spécifiquement TET2 dans WB, ELISA, IHC (p) et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour TET2 anticorps (N-Term) (ABIN6991708)

Antigène: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TET2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-TET2 anticorps

Épitope: AA 20-70, N-Term

Specificité: At least two isoforms of TET2 are known to exist, this antibody will detect both isoforms.

Purification: TET2 Antibody is affinity chromatography purified via peptide column.

Immunogène: TET2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human TET2. The immunogen is located within amino acids 20 - 70 of TET2.

Isotype: IgG

Information d'application

Indications d'application: TET2 antibody can be used for detection of TET2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TET2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TET2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TET2

Antigène: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Autre désignation: TET2

Sujet: TET2 Antibody: TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14 % of patients with JAK2V617F-positive myeloproliferative neoplasms, and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia. Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.

ID gène: 54790

NCBI Accession: NP_001120680

UniProt: Q6N021

Pathways: L'effet Warburg