RGS22 anticorps (N-Term)

N° du produit ABIN6991738

Cet anticorps Lapin Polyclonal détecte spécifiquement RGS22 dans ELISA, WB et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour RGS22 anticorps (N-Term) (ABIN6991738)

Antigène: RGS22 (Regulator of G-Protein Signaling 22 (RGS22))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RGS22 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-RGS22 anticorps

Épitope: AA 870-920, N-Term

Specificité: At least four isoforms of RGS22 are known to exist, this antibody will detect the three longest isoforms. RGS22 antibody is predicted to not cross-react with other RGS proteins

Purification: RGS22 Antibody is affinity chromatography purified via peptide column.

Immunogène: RGS22 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human RGS22. The immunogen is located within amino acids 870 - 920 of RGS22.

Isotype: IgG

Information d'application

Indications d'application: RGS22 antibody can be used for detection of RGS22 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: RGS22 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: RGS22 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur RGS22

Antigène: RGS22 (Regulator of G-Protein Signaling 22 (RGS22))

Autre désignation: RGS22

Sujet: RGS22 Antibody: Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS22 is a recently identified member of this family that localizes to the testis and can interact with guanine nucleotide binding proteins alpha 11, 12, and 13 (GNA11, GNA12, and GNA13). While RGS22 has been postulated to play a role in spermiogenesis in the testis, it is also expressed in several cancer cell lines with an epithelial origin and associated with cancer metastasis. Its overexpression in a highly metastatic cancer causes a decrease in cell migration and a reduction of the invasive potential of the cells, suggesting that RGS22 may be a potential prognostic biomarker for metastasis.

Poids moléculaire: 139 kDa

ID gène: 26166

NCBI Accession: NP_056483

UniProt: Q8NE09

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling