CBX4 anticorps (N-Term)

N° du produit ABIN6991741

Cet anticorps Lapin Polyclonal détecte spécifiquement CBX4 dans WB, ELISA et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour CBX4 anticorps (N-Term) (ABIN6991741)

Antigène: CBX4 (Chromobox Homolog 4 (CBX4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBX4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-CBX4 anticorps

Épitope: AA 50-100, N-Term

Specificité: Two alternatively spliced transcript variants have been observed.

Purification: CBX4 Antibody is affinity chromatography purified via peptide column.

Immunogène: CBX4 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CBX4. The immunogen is located within amino acids 50 - 100 of CBX4.

Isotype: IgG

Information d'application

Indications d'application: CBX4 antibody can be used for detection of CBX4 by Western blot at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: CBX4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: CBX4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur CBX4

Antigène: CBX4 (Chromobox Homolog 4 (CBX4))

Autre désignation: CBX4

Sujet: CBX4 Antibody: Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.

Poids moléculaire: 62 kDa

ID gène: 8535

NCBI Accession: NP_003646

UniProt: O00257