CRB2 anticorps (AA 460-510)

N° du produit ABIN6991796

L’anticorps Lapin Polyclonal anti-CRB2 a été validé pour ELISA et WB. Il convient pour détecter CRB2 dans des échantillons de Humain et Souris.

Aperçu rapide pour CRB2 anticorps (AA 460-510) (ABIN6991796)

Antigène: CRB2 (Crumbs Homolog 2 (CRB2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRB2 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-CRB2 anticorps

Épitope: AA 460-510

Specificité: At least three isoforms of CRB2 are known to exist, this antibody will detect all three. CRB2 antibody is predicted to not cross-react with other members of the CRB family.

Purification: CRB2 Antibody is affinity chromatography purified via peptide column.

Immunogène: Rabbit polyclonal CRB2 antibody was raised against a 17 amino acid peptide near the center of human CRB2. The immunogen is located within amino acids 460 - 510 of CRB2.

Isotype: IgG

Information d'application

Indications d'application: CRB2 antibody can be used for detection of CRB2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: CRB2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: CRB2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur CRB2

Antigène: CRB2 (Crumbs Homolog 2 (CRB2))

Autre désignation: CRB2

Sujet: CRB2 Antibody: CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in developing neuroepithelial cells. At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes. Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins. Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.

Poids moléculaire: Predicted: 105, 129, and 141 kDa

Observed: 103, 128 kDa

ID gène: 286204

NCBI Accession: NP_775960

UniProt: Q5IJ48

Pathways: Signalisation Notch