KREMEN2 anticorps (C-Term)

N° du produit ABIN6991832

Détail du produit anti-KREMEN2 anticorps

Antigène: KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))

Épitope: AA 390-440, C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KREMEN2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Specificité: Multiple isoforms of KREMEN2 are known to exist. KREMEN2 antibody is predicted to not cross-react with other Kremen protein family members.

Purification: KREMEN2 Antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-KREMEN2 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human KREMEN2. The immunogen is located within amino acids 390-440 of KREMEN2.

Isotype: IgG

Information d'application

Indications d'application: WB: 1-2 μ,g/mL, ICC: 5 μ,g/mL.

Antibody validated: Western Blot in human, mouse and rat samples, Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: KREMEN2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: KREMEN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur KREMEN2

Antigène: KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))

Autre désignation: KREMEN2 (KREMEN2 Produits)

Synonymes: anticorps krm2, anticorps KREMEN2, anticorps MGC147633, anticorps KRM2, anticorps 2900054E04Rik, anticorps Krm2, anticorps kringle containing transmembrane protein 2 S homeolog, anticorps kringle containing transmembrane protein 2, anticorps kremen2.S, anticorps KREMEN2, anticorps kremen2, anticorps Kremen2

Sujet: KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.

Poids moléculaire: Predicted: 49kD

Observed: 49kD kDa

ID gène: 79412

NCBI Accession: NP_757384

UniProt: Q8NCW0

Pathways: Signalisation WNT