UNG anticorps (N-Term)

N° du produit ABIN6991863

Détail du produit anti-UNG anticorps

Antigène: UNG (Uracil-DNA Glycosylase (UNG))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UNG est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificité: At least two isoforms of UNG2 are known to exist, this antibody will only detect the longer isoform. UNG2 antibody is predicted to not cross-react with UNG1.

Purification: UNG2 Antibody is affinity chromatography purified via peptide column.

Immunogène: UNG2 antibody was raised against a 17 amino acid peptide near the amino terminus of human UNG2. The immunogen is located within the first 50 amino acids of UNG2.

Isotype: IgG

Information d'application

Indications d'application: UNG2 antibody can be used for detection of UNG2 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: UNG2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: UNG2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur UNG

Antigène: UNG (Uracil-DNA Glycosylase (UNG))

Autre désignation: UNG2 (UNG Produits)

Synonymes: anticorps DGU, anticorps HIGM4, anticorps HIGM5, anticorps UDG, anticorps UNG1, anticorps UNG15, anticorps UNG2, anticorps ung, anticorps zgc:56102, anticorps PSPTO4236, anticorps BA5648, anticorps ECK2578, anticorps JW2564, anticorps An02g14790, anticorps AO090001000732, anticorps DDBDRAFT_0204444, anticorps DDBDRAFT_0214910, anticorps DDB_0204444, anticorps DDB_0214910, anticorps uracil-DNA glycosylase, anticorps uracil DNA glycosylase, anticorps uracil DNA glycosylase a, anticorps uracil-DNA glycosylase Ung, anticorps uracil-DNA-glycosylase, anticorps uracil DNA glycosylase L homeolog, anticorps uracil glycosylase, anticorps temporal expression: early, anticorps ung, anticorps ung2, anticorps Ung, anticorps UNG, anticorps unga, anticorps STY2840, anticorps ung.L, anticorps ANI_1_3358024, anticorps AOR_1_1318164, anticorps uglA, anticorps Arnit_2731, anticorps D4R

Classe de substances: Viral Protein

Sujet: UNG2 Antibody: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promoters and alternative splicing. UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from DNA that arise through either misincorporation during replication or cytosine deamination. UNG2 can also be bound by the HIV-1 integrase and incorporated into the virion particle, suggesting that it is required to remove uracils from the viral genome. As the intrinsic antiviral protein APOBEC3G generates numerous uracils in the HIV genome during its replication, it may be that the UNG2 contributes to the APOBEC3G-mediated loss of infectivity by generating abasic sites in the viral genome.

Poids moléculaire: Predicted: 34 kDa

Observed: 33 kDa

ID gène: 7374

NCBI Accession: NP_550433

UniProt: P13051

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response