UNG anticorps (AA 200-250)

N° du produit ABIN6991910

L’anticorps Lapin Polyclonal anti-UNG a été validé pour WB, ELISA, IF et IHC (p). Il convient pour détecter UNG dans des échantillons de Humain et Souris.

Aperçu rapide pour UNG anticorps (AA 200-250) (ABIN6991910)

Antigène: UNG (Uracil-DNA Glycosylase (UNG))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UNG est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-UNG anticorps

Épitope: AA 200-250

Purification: UNG1 Antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-UNG1 antibody was raised against a peptide corresponding to 14 amino acids near the center of human UNG1. The immunogen is located within amino acids 200-250 of UNG1.

Isotype: IgG

Information d'application

Indications d'application: WB: 0.5-4 μ,g/mL, IHC: 2 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: UNG1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: UNG1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur UNG

Antigène: UNG (Uracil-DNA Glycosylase (UNG))

Autre désignation: UNG1

Sujet: UNG1 Antibody: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner. This UNG1 antibody will not cross-react with UNG2.

Poids moléculaire: Predicted: 34kD

Observed: 34 kD kDa

ID gène: 7374

NCBI Accession: NP_003353

UniProt: P13051

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response