UNG anticorps (AA 200-250)

N° du produit ABIN6991910

Détail du produit anti-UNG anticorps

Antigène: UNG (Uracil-DNA Glycosylase (UNG))

Épitope: AA 200-250

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UNG est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: UNG1 Antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-UNG1 antibody was raised against a peptide corresponding to 14 amino acids near the center of human UNG1. The immunogen is located within amino acids 200-250 of UNG1.

Isotype: IgG

Information d'application

Indications d'application: WB: 0.5-4 μ,g/mL, IHC: 2 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: UNG1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: UNG1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur UNG

Antigène: UNG (Uracil-DNA Glycosylase (UNG))

Autre désignation: UNG1 (UNG Produits)

Synonymes: anticorps DGU, anticorps HIGM4, anticorps HIGM5, anticorps UDG, anticorps UNG1, anticorps UNG15, anticorps UNG2, anticorps ung, anticorps zgc:56102, anticorps PSPTO4236, anticorps BA5648, anticorps ECK2578, anticorps JW2564, anticorps An02g14790, anticorps AO090001000732, anticorps DDBDRAFT_0204444, anticorps DDBDRAFT_0214910, anticorps DDB_0204444, anticorps DDB_0214910, anticorps uracil-DNA glycosylase, anticorps uracil DNA glycosylase, anticorps uracil DNA glycosylase a, anticorps uracil-DNA glycosylase Ung, anticorps uracil-DNA-glycosylase, anticorps uracil DNA glycosylase L homeolog, anticorps uracil glycosylase, anticorps temporal expression: early, anticorps ung, anticorps ung2, anticorps Ung, anticorps UNG, anticorps unga, anticorps STY2840, anticorps ung.L, anticorps ANI_1_3358024, anticorps AOR_1_1318164, anticorps uglA, anticorps Arnit_2731, anticorps D4R

Classe de substances: Viral Protein

Sujet: UNG1 Antibody: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner. This UNG1 antibody will not cross-react with UNG2.

Poids moléculaire: Predicted: 34kD

Observed: 34 kD kDa

ID gène: 7374

NCBI Accession: NP_003353

UniProt: P13051

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response