IL-37 anticorps (N-Term)

N° du produit ABIN6991912

Cet anticorps Lapin Polyclonal détecte spécifiquement IL-37 dans WB, ELISA, IHC (p) et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour IL-37 anticorps (N-Term) (ABIN6991912)

Antigène: IL-37 (IL37) (Interleukin 37 (IL37))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-37 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-IL-37 anticorps

Épitope: AA 30-80, N-Term

Specificité: IL-37 antibody is human specific. Multiple isoforms of IL-37 are known to exist, this antibody will only detect the largest isoform. IL-37 antibody is predicted to not cross-react with IL-36.

Purification: IL-37 Antibody is affinity chromatography purified via peptide column.

Immunogène: IL-37 antibody was raised against a 17 amino acid peptide near the amino terminus of human IL-37. The immunogen is located within amino acids 30 - 80 of IL-37 .

Isotype: IgG

Information d'application

Indications d'application: IL-37 antibody can be used for detection of IL-37 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-37 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: IL-37 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur IL-37

Antigène: IL-37 (IL37) (Interleukin 37 (IL37))

Autre désignation: IL-37

Sujet: Interleukin 37 (IL-37) is a member of the interleukin 1 cytokine family (reviewed in 1). It can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). IL-37 also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18 (1). IL-37 can also interact with Smad3 and expression of IL-37 in macrophages or epithelial cells resulted in near complete suppression of pro-inflammatory cytokines, suggesting that IL-37 may act as a natural suppressor of the innate inflammatory and immune responses (2,3).

Poids moléculaire: Predicted: 24 kDa

Observed: 23kDa

ID gène: 27178

NCBI Accession: NP_055254

UniProt: Q9NZH6