AIMP2 anticorps (AA 150-200)

N° du produit ABIN6991920

Cet anticorps anti-AIMP2 Polyclonal Lapin (ABIN6991920) détecte spécifiquement AIMP2 dans WB, ELISA, IF et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour AIMP2 anticorps (AA 150-200) (ABIN6991920)

Antigène: AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AIMP2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-AIMP2 anticorps

Épitope: AA 150-200

Specificité: AIMP2 antibody is human specific. AIMP2 antibody is predicted to not cross-react with AIMP1.

Purification: AIMP2 antibody is affinity chromatography purified via peptide column.

Immunogène: AIMP2 antibody was raised against a 16 amino acid peptide near the center of human AIMP2. The immunogen is located within amino acids 150 - 200 of AIMP2.

Isotype: IgG

Information d'application

Indications d'application: AIMP2 antibody can be used for detection of AIMP2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: AIMP2 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: AIMP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur AIMP2

Antigène: AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))

Autre désignation: AIMP2

Sujet: AIMP2 was initially identified as a part of an aminoacyl-tRNA synthesase complex (1). It was later discovered to be a cofactor and substrate of Parkin, a Ring-type E3 ubiquitin ligase that is important for the survival of dopamine neurons in Parkinson's disease, accumulation of AIMP2 in these cells lead to catecholaminergic cell death (2). AIMP2 can also bind to TRAF2, a key player in the TNF-alpha signaling pathway, causing the ubiquitination of TRAF2 by cIAP1, leading to TNF-alpha-dependent apoptosis (3). Finally, AIMP2 has been suggested to function as a tumor suppressor (4).

Poids moléculaire: Predicted: 35 kDa

Observed: 36 kDa

ID gène: 7965

NCBI Accession: NP_006294

UniProt: Q13155