TRF2 anticorps (N-Term)
-
- Antigène Voir toutes TRF2 (TERF2) Anticorps
- TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))
-
Épitope
- N-Term
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp TRF2 est non-conjugé
-
Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- TERF2 antibody is human specific.
- Purification
- TERF2 antibody is affinity chromatography purified via peptide column.
- Immunogène
- TERF2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TERF2. The immunogen is located within the first 50 amino acids of TERF2.
- Isotype
- IgG
- Top Product
- Discover our top product TERF2 Anticorps primaire
-
-
- Indications d'application
-
TERF2 antibody can be used for detection of TERF2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- TERF2 Antibody is supplied in PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,4 °C
- Stockage commentaire
- TERF2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
-
- Antigène
- TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))
- Autre désignation
- TERF2 (TERF2 Produits)
- Synonymes
- anticorps TERF2, anticorps TRBF2, anticorps TRF2, anticorps trf2, anticorps telomeric repeat binding factor 2, anticorps telomeric repeat binding factor 2 L homeolog, anticorps TERF2, anticorps Terf2, anticorps terf2.L
- Sujet
- The telomeric repeat binding factor family (TERF1 and TERF2) plays a key role in cellular immortalization and cellular senescence (1). TERF2, as a component of the telomere nucleoprotein complex, is present at telomeres in metaphase of the cell cycle (2). TERF2 is a second negative regulator of telomere length and binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway (2,3). TERF1 negatively regulates telomere elongation, while TERF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression (4,5).
- Poids moléculaire
-
Predicted: 60 kDa
Observed: 69 kDa - ID gène
- 7014
- NCBI Accession
- NP_005643
- UniProt
- Q15554
- Pathways
- Cycle Cellulaire, Telomere Maintenance
-