TXNIP anticorps (AA 110-160)
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- Antigène Voir toutes TXNIP Anticorps
- TXNIP (Thioredoxin Interacting Protein (TXNIP))
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Épitope
- AA 110-160
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TXNIP est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- Specificité
- TXNIP antibody is human, mouse and rat reactive.
- Purification
- TXNIP antibody is affinity chromatography purified via peptide column.
- Immunogène
- TXNIP antibody was raised against a 16 amino acid peptide near the center of human TXNIP. The immunogen is located within amino acids 110 - 160 of TXNIP.
- Isotype
- IgG
- Top Product
- Discover our top product TXNIP Anticorps primaire
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- Indications d'application
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TXNIP body can be used for detection of TXNIP by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for Immunohistochemistry at 2 μ,g/mL. For Immunoflorescence start at 5 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- TXNIP antibody is supplied in PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,4 °C
- Stockage commentaire
- TXNIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- Antigène
- TXNIP (Thioredoxin Interacting Protein (TXNIP))
- Autre désignation
- TXNIP (TXNIP Produits)
- Synonymes
- anticorps EST01027, anticorps HHCPA78, anticorps THIF, anticorps VDUP1, anticorps Gm348, anticorps Trf3, anticorps TBP2, anticorps TRF3, anticorps 1200008J08Rik, anticorps AA682105, anticorps Hyplip1, anticorps Tbp-2, anticorps Vdup1, anticorps sb:cb368, anticorps txnip, anticorps thioredoxin interacting protein, anticorps TATA box binding protein like 2, anticorps TATA-box binding protein like 2, anticorps thioredoxin interacting protein L homeolog, anticorps thioredoxin interacting protein a, anticorps TXNIP, anticorps Tbpl2, anticorps TBPL2, anticorps Txnip, anticorps txnip.L, anticorps txnip, anticorps txnipa
- Sujet
- Thioredoxin-interacting protein (TXNIP) belongs to the arrestin family and plays a critical role in the antioxidant defense mechanisms of hematopoietic cells by activating the p53 pathway during oxidative stress (1,2). It functions as a transcriptional repressor and acts as an oxidative stress mediator by inhibiting thioredoxin activity (2). TXNIP expression is reduced in many types of tumors, and TXNIP overexpression inhibits tumor growth by blocking cell-cycle progression (3). It has recently reported that TXNIP deficiency correlates with a high incidence of hepatocellular carcinoma (HCC) (4). TXNIP and p53 interactions could potentially be a therapeutic target for oxidative stress-related diseases such as hematopoietic malignancies and metabolic diseases (5).
- Poids moléculaire
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Predicted: 43 kDa
Observed: 39 kDa - ID gène
- 10628
- NCBI Accession
- NP_006463
- UniProt
- Q9H3M7
- Pathways
- Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome
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