LC3B anticorps (AA 20-70)

N° du produit ABIN6992057

Détail du produit anti-LC3B anticorps

Antigène: LC3B (MAP1LC3B) (Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B))

Épitope: AA 20-70

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LC3B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: MAP1LC3 antibody is human, mouse and rat reactive. Multiple isoforms MAP1LC3 are known to exist. MAP1LC3 antibody is predicted to detect MAP1LC3A, MAP1LC3B, and MAP1LC3C.

Purification: MAP1LC3 antibody is affinity chromatography purified via peptide column.

Immunogène: MAP1LC3 antibody was raised against a 12 amino acid peptide near the center of human MAP1LC3A. The immunogen is located within amino acids 20 - 70 of MAP1LC3.

Isotype: IgG

Information d'application

Indications d'application: MAP1LC3 antibody can be used for detection of MAP1LC3 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: MAP1LC3 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: MAP1LC3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur LC3B

Antigène: LC3B (MAP1LC3B) (Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B))

Autre désignation: MAP1LC3 (MAP1LC3B Produits)

Synonymes: anticorps ATG8F, anticorps LC3B, anticorps MAP1A/1BLC3, anticorps MAP1LC3B-a, anticorps Map1lc3, anticorps Mpl3, anticorps zbs559, anticorps 1010001C15Rik, anticorps Atg8, anticorps LC3b, anticorps zgc:56434, anticorps wu:fb60g11, anticorps map1lc3b, anticorps MGC76283, anticorps MAP1LC3B, anticorps microtubule associated protein 1 light chain 3 beta, anticorps microtubule-associated protein 1 light chain 3 beta, anticorps microtubule associated protein 1 light chain 3 beta L homeolog, anticorps MAP1LC3B, anticorps Map1lc3b, anticorps map1lc3b, anticorps map1lc3b.L

Sujet: Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and plasticity (1). MAP1LC3 is a subfamily of three related proteins belonging to the MAP1 LC3 family and it includes MAP1LC3A, MAP1LC3B, and MAP1LC3C (2). MAP1LC3 is the mammalian homolog of yeast ATG8 and is essential for autophagy and associated with the autophagosome membranes after processing (3). The three isoforms exhibit distinct expression patterns and both MAP1LC3A and MAP1LC3B but not MAP1LC3B, are post-translationally modified, suggesting the three isoforms may have different physiological functions (4).

Poids moléculaire: Predicted: 13 kDa

Observed: 18 kDa

ID gène: 84557

NCBI Accession: NP_115903

UniProt: Q9H492

Pathways: Autophagy