HES5 anticorps (N-Term)

N° du produit ABIN6992090

L’anticorps Lapin Polyclonal anti-HES5 a été validé pour WB, ELISA, IHC (p) et IF. Il convient pour détecter HES5 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour HES5 anticorps (N-Term) (ABIN6992090)

Antigène: HES5 (Hairy and Enhancer of Split 5 (HES5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HES5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-HES5 anticorps

Épitope: N-Term

Specificité: HES5 antibody is human, mouse and rat reactive. At least two isoforms of HES5 are known to exist, this antibody will detect both isoforms.

Purification: HES5 antibody is affinity chromatography purified via peptide column.

Immunogène: HES5 antibody was raised against a 19 amino acid peptide near the amino terminus of human HES5. The immunogen is located within the first 50 amino acids of HES5.

Isotype: IgG

Information d'application

Indications d'application: HES5 antibody can be used for detection of HES5 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: HES5 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: HES5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur HES5

Antigène: HES5 (Hairy and Enhancer of Split 5 (HES5))

Autre désignation: HES5

Sujet: HES5 is a member of the HES family of transcriptional repressors, which are the mammalian homologs of the Drosophila Hairy and Enhancer of Split and contain basic Helix-loop-helix (bHLH) and Orange domains (1). The HES5 gene is a downstream target of the Notch signaling pathway and its expression is downregulated during human cartilage differentiation (2). HES5 can directly repress transcription of the E3 ligase FBW7-beta, creating a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions (3).

Poids moléculaire: Predicted: 18 kDa

Observed: 17 kDa

ID gène: 388585

NCBI Accession: NP_001010926

UniProt: Q5TA89

Pathways: Stem Cell Maintenance, Tube Formation