Adenosine A2b Receptor anticorps (C-Term)

N° du produit ABIN6992110

Cet anticorps Lapin Polyclonal détecte spécifiquement Adenosine A2b Receptor dans WB, ELISA, IF et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Adenosine A2b Receptor anticorps (C-Term) (ABIN6992110)

Antigène: Adenosine A2b Receptor (ADORA2B)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Adenosine A2b Receptor est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Adenosine A2b Receptor anticorps

Épitope: C-Term

Specificité: ADORA2B antibody is human, mouse and rat reactive. At least two isoforms of ADORA2B are known to exist, this antibody will detect both isoforms. ADORA2B antibody is predicted to not cross-react with ADORA2A.

Purification: ADORA2B antibody is affinity chromatography purified via peptide column.

Immunogène: ADORA2B antibody was raised against a 19 amino acid peptide near the carboxy terminus of human ADORA2B. The immunogen is located within the last 50 amino acids of ADORA2B.

Isotype: IgG

Information d'application

Indications d'application: ADORA2B antibody can be used for detection of ADORA2B by Western blot at 0.25 - 0.5 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ADORA2B antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ADORA2B antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur Adenosine A2b Receptor

Antigène: Adenosine A2b Receptor (ADORA2B)

Autre désignation: ADORA2B

Sujet: The adenosine receptor ADORA2B is a member of the G protein-coupled receptor superfamily and is an integral membrane protein that stimulates adenylate cyclase activity in the presence of adenosine (1,2). Extracellular adenosine triggers a potent anti-inflammatory response that is mediated in part by ADORA2B including the stimulation of IL-10 production (3-5). Activation of ADORA2B can also enhance the abundance of regulatory T cells (Tregs), a class of cells that work to constrain inflammation (6).

Poids moléculaire: Predicted: 37 kDa

Observed: 41 kDa

ID gène: 136

NCBI Accession: NP_000667

UniProt: P29275

Pathways: cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process