ADRM1 anticorps (AA 210-260)

N° du produit ABIN6992113

Cet anticorps Lapin Polyclonal détecte spécifiquement ADRM1 dans WB, ELISA et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ADRM1 anticorps (AA 210-260) (ABIN6992113)

Antigène: ADRM1 (Adrm1) (Adhesion Regulating Molecule 1 (Adrm1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADRM1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ADRM1 anticorps

Épitope: AA 210-260

Specificité: ADRM1 antibody is human, mouse and rat reactive. At least two isoforms of ADRM1 are know to exist, this antibody will detect both isoforms.

Purification: ADRM1 antibody is affinity chromatography purified via peptide column.

Immunogène: ADRM1 antibody was raised against a 19 amino acid peptide near the center of human ADRM1. The immunogen is located within amino acids 210 - 260 of ADRM1.

Isotype: IgG

Information d'application

Indications d'application: ADRM1 antibody can be used for detection of ADRM1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ADRM1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ADRM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur ADRM1

Antigène: ADRM1 (Adrm1) (Adhesion Regulating Molecule 1 (Adrm1))

Autre désignation: ADRM1

Sujet: The adhesion-regulating molecule 1 (ADRM1) is thought to be involved in protein recruitment and cell adhesion and functions as a proteasomal ubiquitin receptor (1). ADRM1 promotes the activity of UCH-L5 and plays a role in lymphocyte homing. The carboxy-terminal domain of mammalian ADRM1 serves to bind and enhance the isopeptidase activity of UCHL5/UCH37, perhaps serving as a mechanism to accelerate ubiquitin chain disassembly (2,3). ADRM1 expression is induced by IFN-gamma in some cancer cell lines and its expression is upregulated in other metastatic cells, suggesting a role in carcinogenesis (4,5).

Poids moléculaire: Predicted: 45 kDa

Observed: 48 kDa

ID gène: 11047

NCBI Accession: NP_783163

UniProt: Q16186

Pathways: Positive Regulation of Endopeptidase Activity