ADRM1 anticorps (AA 210-260)

N° du produit ABIN6992113

Détail du produit anti-ADRM1 anticorps

Antigène: ADRM1 (Adrm1) (Adhesion Regulating Molecule 1 (Adrm1))

Épitope: AA 210-260

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADRM1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: ADRM1 antibody is human, mouse and rat reactive. At least two isoforms of ADRM1 are know to exist, this antibody will detect both isoforms.

Purification: ADRM1 antibody is affinity chromatography purified via peptide column.

Immunogène: ADRM1 antibody was raised against a 19 amino acid peptide near the center of human ADRM1. The immunogen is located within amino acids 210 - 260 of ADRM1.

Isotype: IgG

Information d'application

Indications d'application: ADRM1 antibody can be used for detection of ADRM1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ADRM1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ADRM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur ADRM1

Antigène: ADRM1 (Adrm1) (Adhesion Regulating Molecule 1 (Adrm1))

Autre désignation: ADRM1 (Adrm1 Produits)

Synonymes: anticorps arm-1, anticorps gp110, anticorps rpn13, anticorps xoom, anticorps ADRM1, anticorps adrm1, anticorps ARM-1, anticorps ARM1, anticorps GP110, anticorps 1110063P18Rik, anticorps 2510006J17Rik, anticorps AA408205, anticorps AU043535, anticorps Arm1, anticorps Gp110, anticorps Rpn13, anticorps adrm1a, anticorps adrm1b, anticorps fa12d09, anticorps wu:fa10g10, anticorps wu:fa12d09, anticorps zgc:56107, anticorps zgc:77256, anticorps adhesion regulating molecule 1, anticorps ADRM1, anticorps 19S proteasome regulatory subunit, anticorps ADRM1 protein, anticorps adrm1, anticorps ADRM1, anticorps CpipJ_CPIJ002929, anticorps SJAG_04211, anticorps Adrm1

Sujet: The adhesion-regulating molecule 1 (ADRM1) is thought to be involved in protein recruitment and cell adhesion and functions as a proteasomal ubiquitin receptor (1). ADRM1 promotes the activity of UCH-L5 and plays a role in lymphocyte homing. The carboxy-terminal domain of mammalian ADRM1 serves to bind and enhance the isopeptidase activity of UCHL5/UCH37, perhaps serving as a mechanism to accelerate ubiquitin chain disassembly (2,3). ADRM1 expression is induced by IFN-gamma in some cancer cell lines and its expression is upregulated in other metastatic cells, suggesting a role in carcinogenesis (4,5).

Poids moléculaire: Predicted: 45 kDa

Observed: 48 kDa

ID gène: 11047

NCBI Accession: NP_783163

UniProt: Q16186

Pathways: Positive Regulation of Endopeptidase Activity