CTLA4 anticorps (Extracellular Domain)

N° du produit ABIN6992223

Cet anticorps anti-CTLA4 Monoclonal Souris (Clone 1E6) (ABIN6992223) détecte spécifiquement CTLA4 dans WB, ELISA, ICC, IF et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CTLA4 anticorps (Extracellular Domain) (ABIN6992223)

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CTLA4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1E6

Détail du produit anti-CTLA4 anticorps

Épitope: Extracellular Domain

Purification: CTLA-4 Antibody is supplied as protein A purified IgG1.

Immunogène: CTLA-4 antibody was raised against the extracellular domain of human CTLA-4.

Isotype: IgG1

Information d'application

Indications d'application: CTLA-4 antibody can be used for detection of CTLA-4 by Western blot at 0.125 - 0.25 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: CTLA-4 Antibody is supplied in PBS containing 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: CTLA-4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur CTLA4

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Autre désignation: CTLA4

Sujet: The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), also known as CD152, is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells (1,2). Both it and the homologous T-cell co-stimulatory protein CD28 bind to CD80 (B7-H1) and CD86 (B7-H2) on antigen-presenting cells (APCs) (3). Mutations in the CTLA-4 gene have been implicated in multiple autoimmune diseases (4). CTLA-4 also functions as an immune checkpoint protein, and anti- CTLA-4 antibodies have been successfully used in the treatment of cancer (5).

Poids moléculaire: Predicted: 25 kDa

Observed: 32 kDa

ID gène: 1493

NCBI Accession: NP_005205

UniProt: P16410

Pathways: Cancer Immune Checkpoints