RIPK3 anticorps (C-Term)

N° du produit ABIN6992283

Cet anticorps anti-RIPK3 Polyclonal Lapin (ABIN6992283) détecte spécifiquement RIPK3 dans WB, ELISA, IHC (p) et IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour RIPK3 anticorps (C-Term) (ABIN6992283)

Antigène: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RIPK3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-RIPK3 anticorps

Épitope: C-Term

Specificité: Several isoforms of hRIP3 are known to exist.

Purification: hRIP3 Antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-hRIP3 antibody was raised against a peptide corresponding to 18 amino acids near the carboxy terminus of human hRIP3. The immunogen is located within the last 50 amino acids of hRIP3.

Isotype: IgG

Information d'application

Indications d'application: WB: 0.5-1 μ,g/mL, IF: 20 μ,g/mL, IHC: 2-5 μ,g/mL.

Antibody validated: Western Blot, Immunofluorescence and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: hRIP3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: hRIP3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur RIPK3

Antigène: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Autre désignation: hRIP3

Sujet: HRIP3 Antibody: Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-?B activation. Overexpression of RIP3 induces apoptosis and NF-?B activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.

Poids moléculaire: Predicted: 57kD

Observed: 57 kD kDa

ID gène: 11035

UniProt: Q9Y572

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades