Cet anticorps Lapin Polyclonal détecte spécifiquement RENT1/UPF1 dans WB, IHC et ELISA. Il présente une réactivité avec des échantillons de Humain et Souris.
UPF1
Reactivité: Humain
ELISA, IF
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB 1:200-1:1000, IHC 1:50-1:200
Restrictions
For Research Use only
Format
Liquid
Concentration
0.1 mg/mL
Buffer
PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Stockage commentaire
Store at -20°C. Avoid freeze / thaw cycles.
Antigène
RENT1/UPF1 (UPF1)
(UPF1 Regulator of Nonsense Transcripts Homolog (UPF1))
Autre désignation
UPF1
Sujet
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in botHuman, MouseRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.