XAB2 anticorps

N° du produit ABIN7004725

Détail du produit anti-XAB2 anticorps

Antigène: XAB2 (XPA Binding Protein 2 (XAB2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XAB2 est non-conjugé

Application: Western Blotting (WB), ELISA

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of human XAB2

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur XAB2

Antigène: XAB2 (XPA Binding Protein 2 (XAB2))

Autre désignation: XAB2 (XAB2 Produits)

Synonymes: anticorps Dmel\\CG6197, anticorps Prp5, anticorps XAB2, anticorps Xab2, anticorps zgc:63498, anticorps zgc:63949, anticorps HCNP, anticorps HCRN, anticorps NTC90, anticorps SYF1, anticorps 0610041O14Rik, anticorps AV025587, anticorps Ath55, anticorps fandango, anticorps XPA binding protein 2, anticorps XPA binding protein 2 L homeolog, anticorps fand, anticorps xab2, anticorps XAB2, anticorps xab2.L, anticorps Xab2

Sujet: HCNP, also known as XAB2 (Xeroderma pigmentosum group A (XPA) binding protein 2), HCRN, SYF1 or NTC90, is a nuclear protein that participates in transcription, transcription-coupled repair (TCR) and pre-mRNA splicing. It contains fifteen tetratricopeptide repeat motifs and associates with nucleotide excision repair machinery. More specifically, HCNP associates with Cockayne syndrome group A and B proteins (CSA and CSB), RNA Polymerase II (Pol II) and XPA in response to DNA damage and is believed to function in the TCR pathway. HCNP also functions as an essential component of a pre-mRNA splicing complex of the spliceosome (composed of AQR (aquarius), PRP19, CCDC16, HCNP, ISY1 and Cyclophilin E) and is required for proper RNA synthesis in the cell. In addition, HCNP functions as a component of the RAR corepressor complex with RAR and HDAC3 and exhibits an inhibitory effect on ATRA-induced cell differentiation. This suggests that HCNP may function as useful target in cancer therapy.

Poids moléculaire:

Observed_MW: Refer to figures

Calculated_MW: 100 kDa

UniProt: Q9HCS7