beta Catenin anticorps

N° du produit ABIN7250260

L’anticorps Souris Monoclonal anti-beta Catenin a été validé pour WB, IF et IHC (p). Il convient pour détecter beta Catenin dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour beta Catenin anticorps (ABIN7250260)

Antigène: beta Catenin (CATNB) (Catenin, beta (CATNB))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta Catenin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 2E4

Détail du produit anti-beta Catenin anticorps

Attributs du produit: Monoclonal Antibody

Purification: Protein A purification

Immunogène: Recombinant Protein

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.4.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur beta Catenin

Antigène: beta Catenin (CATNB) (Catenin, beta (CATNB))

Autre désignation: Catenin beta

Sujet: Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

Poids moléculaire: 92 kDa

UniProt: P35222

Pathways: Peptide Hormone Metabolism